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3,4-Difluoroamphetamine

From Wikipedia, the free encyclopedia
Designer drug of the substituted amphetamine class
Pharmaceutical compound
3,4-Difluoroamphetamine
Identifiers
  • 1-(3-Chlorophenyl)-N-methylpropan-2-amine
CAS Number
PubChemCID
ChemSpider
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC9H11F2N
Molar mass171.191 g·mol−1
3D model (JSmol)
  • CC(CC1=CC(=C(C=C1)F)F)N
  • InChI=1S/C9H11F2N/c1-6(12)4-7-2-3-8(10)9(11)5-7/h2-3,5-6H,4,12H2,1H3
  • Key:GJEXOPSQWJWJRQ-UHFFFAOYSA-N

3,4-Difluoroamphetamine (DFA) is asubstituted amphetamine which has been sold as adesigner drug. It has relatively weak activity as aserotonin releasing agent with only around 1/4 of theaffinity for theserotonin transporter compared toMDA, but its activity at other targets has not been studied.[1][2]

See also

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References

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  1. ^Roman DL, Saldaña SN, Nichols DE, Carroll FI, Barker EL (February 2004). "Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters".The Journal of Pharmacology and Experimental Therapeutics.308 (2):679–687.doi:10.1124/jpet.103.057836.PMID 14593087.S2CID 6439942.
  2. ^Walline CC, Nichols DE, Carroll FI, Barker EL (June 2008)."Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition".The Journal of Pharmacology and Experimental Therapeutics.325 (3):791–800.doi:10.1124/jpet.108.136200.PMC 2637348.PMID 18354055.


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