The2006 South Carolina State Bulldogs football team representedSouth Carolina State University as a member of theMid-Eastern Athletic Conference (MEAC) during the2006 NCAA Division I FCS football season. Led by fifth-year head coachOliver Pough, the Bulldogs compiled an overall record of 7–4, with a mark of 6–2 in conference play, and finished tied for second in the MEAC.

Date	Opponent	Site	Result	Attendance	Source
September 2	atWofford*	Gibbs Stadium Spartanburg, SC	L 21–28	11,738	[1]
September 9	atWinston-Salem State*	Bowman Gray Stadium Winston-Salem, NC	W 35–6		[2]
September 16	Bethune–Cookman	Johnson Hagood Stadium Charleston, SC	L 21–45	15,825	[3][4]
September 23	atCoastal Carolina*	Brooks Stadium Conway, SC	L 14–33	9,287	[5]
October 7	Norfolk State	Oliver C. Dawson Stadium Orangeburg, SC	W 47–10	15,304	[6]
October 14	atFlorida A&M	Bragg Memorial Stadium Tallahassee, FL	W 28–21	10,124	[7]
October 21	No. 11Hampton	Oliver C. Dawson Stadium Orangeburg, SC	W 13–6	9,090	[8]
October 28	atDelaware State	Alumni Stadium Dover, DE	L 9–10	2,512	[9]
November 4	Howard	Oliver C. Dawson Stadium Orangeburg, SC	W 28–10	18,155	[10]
November 11	atMorgan State	Hughes Stadium Baltimore, MD	W 41–16	2,876	[11]
November 18	vs.North Carolina A&T	American Legion Memorial Stadium Charlotte, NC (rivalry)	W 41–19	10,126	[12]
*Non-conference game Homecoming Rankings fromThe Sports Network Poll released prior to the game

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