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Deubiquitinating PCNA: a downside to DNA damage tolerance
Nature Cell Biologyvolume 8, pages303–305 (2006)Cite this article
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Monoubiquitination of the processivity clamp, PCNA, facilitates the replicative bypass of DNA lesions by recruiting damage-tolerant polymerases. In undamaged cells, deubiquitination of PCNA by the deubiquitinating enzyme USP1 reveals a possible safeguard mechanism against the mutagenic effect of these polymerases. Intriguingly, USP1 itself seems to be downregulated by a damage-induced autocatalytic cleavage event.
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the Cancer Research UK Clare Hall Laboratories, Blanche Lane, South Mimms, Herts, EN6 3LD, UK
Helle D. Ulrich
- Helle D. Ulrich
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Ulrich, H. Deubiquitinating PCNA: a downside to DNA damage tolerance.Nat Cell Biol8, 303–305 (2006). https://doi.org/10.1038/ncb0406-303
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