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Summary
Two novel prenylat flavones, termed Cannflavin A and B, were isolated from the cannabinoid free ethanolic extract ofCannabis sativa L. Both compounds inhibited prostaglandin E2 production by human rheumatoid synovial cells in culture.
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References
Kosviner, A., in: Cannabis and Health, chapt. 10, p. 343. Ed. J. D. P. Graham. Academic Press, London, New York 1976.
Barrett, M. L., Ph.D. thesis, University of London, Faculty of Medicine (1985).
Gill, E. W., Paton, W. D. H., and Pertwee, R. J., Nature228 (1970) 135.
Burstein, S. and Hunker, S., Rev. appl. Pharmac. Sci.2 (1981) 155.
Fairbairn, J. W. and Pickens, J. T., Br. J. Pharmac.72 (1981) 401.
Fairbairn, J. W., and Pickens, J. T., unpublished work (1981).
Barrett, M. L., Gordon, D., Scutt, A. M., and Evans, F.J., IUPAR, 9th Int. Congr. Pharmac., London 1984, and Barrett, M.L., Gordon, D., and Evans, F. J., Biochem. Pharmac.34 (1985) 2019.
Voirin, B., Phytochemistry22 (1983) 2107.
Mabry, T. J., Markham, K. R., and Thomas, M. B., The Systematic identification of flavonoids, chap. 4, p. 35. Springer-Verlag, Berlin 1970.
Deshpande, V. H., Rama Rao, A. V., Ventataraman, K., and Wakharker, P. V., Indian J. Chem.12 (1974) 431.
Budzikiewicz, H., Mechovlam, R., and Gaoni, Y., Tetrahedron21 (1965) 1881.
Markham, K. R., and Chari, V. M., The Flavonoids, Advances in Research, chap. 2, p. 19. J. B. Harborne, and T. J. Mabry. Chapman and Hall Ltd., 1982.
Chari, V. M., Ahmed, S., and Osterdahl, B. G., Z. Naturforsch.33b (1978) 1547.
O'Neill, M. J., Z. Naturforsch.38c (1983) 698.
Radhakrishnan, P. V., Rama Rao, A. V., and Venkataraman, K., Tetrahedron Lett.1965, 663.
Author information
M. L. Barrett
Present address: Dept. of Pharmacology, Institute of Basic Medical Sciences, Royal College of Surgeons of England, Lincoln's Inn Fields, WC2A 3PN, London
A. M. Scutt
Present address: Dept. of Oral and Maxillofacial Surgery, Institute of Dental Surgery, Grays Inn Road, WC1X 8LD, London
Authors and Affiliations
Department of Pharmacognosy, The School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX, London, England
M. L. Barrett, A. M. Scutt & F. J. Evans
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Additional information
This communication is dedicated to the memory of the late Professor J. W. Fairbairn and the late Dr. J. T. Pickens. We are grateful to the Medical Research Council for a project grant and to Ms J. Elliot of King's College London for NMR spectra.
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Barrett, M.L., Scutt, A.M. & Evans, F.J. Cannflavin A and B, prenylated flavones fromCannabis sativa L..Experientia42, 452–453 (1986). https://doi.org/10.1007/BF02118655
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