| dbo:abstract | - Samidorphan ist ein Arzneistoff aus der Gruppe der Opioidantagonisten. Der Wirkstoff bindet mit hoher Affinität kompetetiv insbesondere an μ-Opioidrezeptoren. (de)
- Samidorphan (INN, USAN) (developmental code names ALKS-33, RDC-0313), is an opioid antagonist which in the form of olanzapine/samidorphan (brand name Lybalvi) is used in the treatment of schizophrenia and bipolar disorder. Samidorphan reduces the weight gain associated with olanzapine. Samidorphan is taken by mouth. Samidorphan was under development as a standalone medication for various indications but has been discontinued. Buprenorphine/samidorphan for the treatment of major depressive disorder was rejected by the Food and Drug Administration due to insufficient evidence of effectiveness but remains in preregistration as of September 2021. Development of has also been discontinued. (en)
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| dbp:stdinchikey | - RYIDHLJADOKWFM-MAODMQOUSA-N (en)
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| dbp:synonyms | - ALKS-33; RDC-0313; 3-Carboxamido-4-hydroxynaltrexone (en)
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| rdfs:comment | - Samidorphan ist ein Arzneistoff aus der Gruppe der Opioidantagonisten. Der Wirkstoff bindet mit hoher Affinität kompetetiv insbesondere an μ-Opioidrezeptoren. (de)
- Samidorphan (INN, USAN) (developmental code names ALKS-33, RDC-0313), is an opioid antagonist which in the form of olanzapine/samidorphan (brand name Lybalvi) is used in the treatment of schizophrenia and bipolar disorder. Samidorphan reduces the weight gain associated with olanzapine. Samidorphan is taken by mouth. (en)
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| rdfs:label | - Samidorphan (en)
- Samidorphan (de)
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