| dbo:abstract | - Neurotrophic factor receptors or neurotrophin receptors are a group of growth factor receptors which specifically bind to neurotrophins (neurotrophic factors). Two classes of neurotrophic factor receptors are the p75 and the "Trk" families of Tyrosine kinases receptors. * p75 is a low affinity neurotrophin receptor, to which all neurotrophins bind. It is a member of the tumour necrosis super family. In some contexts, the phrase "x" only applies to this receptor. * The Trk family include TrkA, TrkB, and TrkC, and will only bind with specific neurotrophins, but with a much higher affinity. The Trks mediate the functional signals of the neurotrophins. * NGF binds to TrkA, BDNF and NT-4 bind to TrkB and NT-3 binds to TrkC. In addition NT-3 also binds to and activates TrkA and TrkB but it does so less efficiently. * Whilst the Trk receptors have a clearly defined trophic role, p75 receptors activate signalling pathways which can also result in apoptosis. (en)
- 神经生长因子受体（英語：Nerve growth factor receptor）是一类与神经营养因子特异性结合的生长因子受体。 有两类神经生长因子受体：（p75等）和属于受体酪氨酸激酶的Trk受体家族。 * p75是一种低亲和力神经生长因子受体，可以与所有神经营养因子结合，是超家族的一员。在一些文献中，代号"x"也指这个受体 * Trk受体家族包括、与，只与特定的神经营养因子结合，但具有较高的亲和力。Trk受体家族可以作為神經營養因子的媒介，使其可以發揮信號作用。 * NGF會與TrkA結合，BDNF和會與結合，會與結合。此外NT-3也會與TrkA和TrkB結合並發揮活性，但功能並不如與TrkC結合時那樣顯著。 * 一方面Trk受体具有明确的营养作用，但另一方面p75受体激活的信号通路也能导致细胞凋亡。 (zh)
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| rdfs:comment | - 神经生长因子受体（英語：Nerve growth factor receptor）是一类与神经营养因子特异性结合的生长因子受体。 有两类神经生长因子受体：（p75等）和属于受体酪氨酸激酶的Trk受体家族。 * p75是一种低亲和力神经生长因子受体，可以与所有神经营养因子结合，是超家族的一员。在一些文献中，代号"x"也指这个受体 * Trk受体家族包括、与，只与特定的神经营养因子结合，但具有较高的亲和力。Trk受体家族可以作為神經營養因子的媒介，使其可以發揮信號作用。 * NGF會與TrkA結合，BDNF和會與結合，會與結合。此外NT-3也會與TrkA和TrkB結合並發揮活性，但功能並不如與TrkC結合時那樣顯著。 * 一方面Trk受体具有明确的营养作用，但另一方面p75受体激活的信号通路也能导致细胞凋亡。 (zh)
- Neurotrophic factor receptors or neurotrophin receptors are a group of growth factor receptors which specifically bind to neurotrophins (neurotrophic factors). Two classes of neurotrophic factor receptors are the p75 and the "Trk" families of Tyrosine kinases receptors. (en)
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| rdfs:label | - Neurotrophic factor receptor (en)
- 神经生长因子受体 (zh)
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