| dbo:abstract | - Myeloperoxidase deficiency is a disorder featuring lack in either the quantity or the function of myeloperoxidase–an iron-containing protein expressed primarily in neutrophil granules. There are two types of myeloperoxidase deficiency: primary/inherited and secondary/acquired. Lack of functional myeloperoxidase leads to less efficient killing of intracellular pathogens, particularly Candida albicans, as well as less efficient production and release of neutrophil extracellular traps (NETs) from the neutrophils to trap and kill extracellular pathogens. Despite these characteristics, more than 95% of individuals with myeloperoxidase deficiency experience no symptoms in their lifetime. For those who do experience symptoms, the most common symptom is frequent infections by Candida albicans. Individuals with myeloperoxidase deficiency also experience higher rates of chronic inflammatory conditions. Myeloperoxidase deficiency is diagnosed using flow cytometry or cytochemical stains. There is no treatment for myeloperoxidase deficiency itself. Rather, in the rare cases that individuals experience symptoms, these infections should be treated. (en)
- Niedobór mieloperoksydazy – rzadkie genetycznie uwarunkowane schorzenie polegające na niedoborze występującego w neutrofilach enzymu mieloperoksydazy, które spowodowane jest mutacją genu mieloperoksydazy (MPO). Niedobór mieloperoksydazy powoduje wadę układu immunologicznego, charakteryzujące się występowaniem kandydiazy. (pl)
- Дефіцит Мієлопероксидази — рідкісна хвороба, первинний імунодефіцит, (генетичне захворювання) що досить поширене у людей. Його переважно зумовлює arg569-to-trp-мутація в локусі 17q23.1 гена мієлопероксидаза.; (uk)
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| dbp:caption | - Hypochlorous acid is normally produced by myeloperoxidase (en)
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| rdfs:comment | - Niedobór mieloperoksydazy – rzadkie genetycznie uwarunkowane schorzenie polegające na niedoborze występującego w neutrofilach enzymu mieloperoksydazy, które spowodowane jest mutacją genu mieloperoksydazy (MPO). Niedobór mieloperoksydazy powoduje wadę układu immunologicznego, charakteryzujące się występowaniem kandydiazy. (pl)
- Дефіцит Мієлопероксидази — рідкісна хвороба, первинний імунодефіцит, (генетичне захворювання) що досить поширене у людей. Його переважно зумовлює arg569-to-trp-мутація в локусі 17q23.1 гена мієлопероксидаза.; (uk)
- Myeloperoxidase deficiency is a disorder featuring lack in either the quantity or the function of myeloperoxidase–an iron-containing protein expressed primarily in neutrophil granules. There are two types of myeloperoxidase deficiency: primary/inherited and secondary/acquired. Lack of functional myeloperoxidase leads to less efficient killing of intracellular pathogens, particularly Candida albicans, as well as less efficient production and release of neutrophil extracellular traps (NETs) from the neutrophils to trap and kill extracellular pathogens. Despite these characteristics, more than 95% of individuals with myeloperoxidase deficiency experience no symptoms in their lifetime. For those who do experience symptoms, the most common symptom is frequent infections by Candida albicans. Ind (en)
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| rdfs:label | - Myeloperoxidase deficiency (en)
- Niedobór mieloperoksydazy (pl)
- Дефіцит мієлопероксидази (uk)
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