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About:Fluorometholone acetate

An Entity of Type:chemical substance,from Named Graph:http://dbpedia.org,within Data Space:dbpedia.org

Fluorometholone acetate, also known as oxylone acetate and sold under the brand names Flarex, Florate, and Omnitrol, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester, as well as a progestogen and progestogen ester. It is the C17α acetate ester of fluorometholone.

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  • Fluorometholone acetate, also known as oxylone acetate and sold under the brand names Flarex, Florate, and Omnitrol, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester, as well as a progestogen and progestogen ester. It is the C17α acetate ester of fluorometholone. In addition to its potent corticosteroid activity, fluorometholone acetate is a progestogen. It has been studied in the treatment of breast cancer in women and has been found to be effective, producing remission in about 20% of women with advanced breast cancer at an oral dosage of 50 mg/day. However, it also produces severe Cushing's syndrome-like symptoms like plethora, moon face, glycosuria, marked weight gain, hypertension, and osteoporosis at this dosage due to its glucocorticoid activity. (en)
dbo:alternativeName
  • Flarex, Florate, Omnitrol (en)
dbo:casNumber
  • 3801-06-7
dbo:chEBI
  • 78354
dbo:chEMBL
  • 1201064
dbo:class
dbo:fdaUniiCode
  • 9I50C3I3OK
dbo:kegg
  • D04221
dbo:pubchem
  • 240767
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  • 4138514 (xsd:integer)
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  • 5394 (xsd:nonNegativeInteger)
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  • 1084543185 (xsd:integer)
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  • 24 (xsd:integer)
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  • 3801-06-07 (xsd:date)
dbp:chebi
  • 78354 (xsd:integer)
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  • 1201064 (xsd:integer)
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  • 210390 (xsd:integer)
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dbp:f
  • 1 (xsd:integer)
dbp:h
  • 31 (xsd:integer)
dbp:iupacName
  • [-17-acetyl-9-fluoro-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate (en)
dbp:kegg
  • D04221 (en)
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  • 5 (xsd:integer)
dbp:pubchem
  • 240767 (xsd:integer)
dbp:smiles
  • [H][C@@]12CC[C@][C@@]1C[C@][C@@]1[C@@]2C[C@]C2=CCC=C[C@]12C (en)
dbp:stdinchi
  • 1 (xsd:integer)
dbp:synonyms
  • Oxylone acetate; 1-Dehydro-9α-fluoro-11β,17α-dihydroxy-6α-methylprogesterone 17α-acetate; 17α-Acetoxy-9α-fluoro-11β-hydroxy-6α-methylpregna-1,4-diene-3,20-dione (en)
dbp:tradename
  • Flarex, Florate, Omnitrol (en)
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  • 9 (xsd:integer)
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  • 225 (xsd:integer)
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  • Fluorometholone acetate, also known as oxylone acetate and sold under the brand names Flarex, Florate, and Omnitrol, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester, as well as a progestogen and progestogen ester. It is the C17α acetate ester of fluorometholone. (en)
rdfs:label
  • Fluorometholone acetate (en)
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