The crucifix of San Marcello is a medieval work of religious art that is venerated in the Oratory of Santissimo Crocifisso of the Church of San Marcello al Corso in Rome. Having survived a fire that destroyed the church in 1519, the crucifix was popularly believed to possess intercessory powers. During an epidemic of plague in 1522 the crucifix was carried in a procession through the city. According to popular belief at the time, the procession caused the plague to leave the neighborhoods through which the crucifix passed, and eventually to die out in Rome.