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About:Calsyntenin

An Entity of Type:protein,from Named Graph:http://dbpedia.org,within Data Space:dbpedia.org

Calsyntenins (Csts, CLSTN) are type I transmembrane proteins that belong to the cadherin superfamily. Their name comes from their ability to bind calcium. In birds and mammals, they consist of three family members (Cst1, 2 and 3), in nematodes one ortholog (CASY-1, originally CDH11) is known.

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dbo:abstract
  • Calsyntenins (Csts, CLSTN) are type I transmembrane proteins that belong to the cadherin superfamily. Their name comes from their ability to bind calcium. In birds and mammals, they consist of three family members (Cst1, 2 and 3), in nematodes one ortholog (CASY-1, originally CDH11) is known. Cst1 (CLSTN1) was first shown to be predominantly expressed in postsynaptic membranes of excitatory neurons, Cst2 and 3 were found in an increased manner in inhibitory GABAergic neurons, in adult and embryonic tissue. Calsyntenins interact with numerous proteins such as with kinesin-1 and the APP-linker protein X11L/Mint2, and were shown to have multi-purpose functions both within and outside the nervous system. Shortly after the calsyntenins were discovered, they were found to regulate postsynaptic calcium concentration. Later it was found that another key-function is to link vesicles to kinesin light chain (KLC) and thus to co-determine transport of distinct cargo. Recent studies identified a role for calsyntenin 1 in the regulation of vesicular trafficking of guidance receptors in dI1 axons at choice points. In cooperation with RabGDI (Guanosine nucleotide dissociation inhibitor), calsyntenin 1 shuttles Rab11-positive vesicles containing Robo1 to the growth cone surface in a precisely regulated manner. By contrast, calsyntenin 1-mediated trafficking of frizzled 3, a guidance receptor in the Wnt pathway, is independent of RabGDI. Calsyntenin gene expression also elevates during oxidative stress in PC12 cells (en)
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  • CLSTN
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  • 25291072 (xsd:integer)
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  • 6401 (xsd:nonNegativeInteger)
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  • 1087330488 (xsd:integer)
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dbp:interpro
  • IPR026914 (en)
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  • 241 (xsd:integer)
dbp:name
  • Calsyntenin (en)
dbp:symbol
  • CLSTN (en)
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rdfs:comment
  • Calsyntenins (Csts, CLSTN) are type I transmembrane proteins that belong to the cadherin superfamily. Their name comes from their ability to bind calcium. In birds and mammals, they consist of three family members (Cst1, 2 and 3), in nematodes one ortholog (CASY-1, originally CDH11) is known. (en)
rdfs:label
  • Calsyntenin (en)
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