Monte Carlo simulation framework for different randomized clinical trial designs with a special emphasis on estimators based on covariate adjustment. The package implements regression-based covariate adjustment (Rosenblum & van der Laan (2010) <doi:10.2202/1557-4679.1138>) and a one-step estimator (Van Lancker et al (2024) <doi:10.48550/arXiv.2404.11150>) for trials with continuous, binary and count outcomes. The estimation of the minimum sample-size required to reach a specified statistical power for a given estimator uses bisection to find an initial rough estimate, followed by stochastic approximation (Robbins-Monro (1951) <doi:10.1214/aoms/1177729586>) to improve the estimate, and finally, a grid search to refine the estimate in the neighborhood of the current best solution.
| Version: | 0.1.0 |
| Depends: | R (≥ 4.1),lava (≥ 1.8.0) |
| Imports: | data.table (≥ 1.14),logger (≥ 0.2.2), methods,progressr,R6 (≥ 2.5.1),survival,targeted (≥ 0.6),rlang |
| LinkingTo: | Rcpp (≥ 1.0.11),RcppArmadillo |
| Suggests: | future,tinytest,MASS,geepack,covr,pdftools,knitr,mets (≥ 1.3.4),rmarkdown,magick,pwr,pwrss |
| Published: | 2025-11-13 |
| DOI: | 10.32614/CRAN.package.carts |
| Author: | Benedikt Sommer [aut, cre], Klaus K. Holst [aut], Foroogh Shamsi [aut], Novo Nordisk A/S [cph] |
| Maintainer: | Benedikt Sommer <benediktsommer92 at gmail.com> |
| BugReports: | https://github.com/NovoNordisk-OpenSource/carts/issues |
| License: | Apache License (≥ 2) |
| URL: | https://novonordisk-opensource.github.io/carts/,https://github.com/NovoNordisk-OpenSource/carts |
| NeedsCompilation: | yes |
| Materials: | README,NEWS |
| CRAN checks: | carts results |
| Reference manual: | carts.html ,carts.pdf |
| Vignettes: | Getting started (source,R code) Parametrization of the negative binomial and gamma distribution (source,R code) |
| Package source: | carts_0.1.0.tar.gz |
| Windows binaries: | r-devel:carts_0.1.0.zip, r-release:carts_0.1.0.zip, r-oldrel:carts_0.1.0.zip |
| macOS binaries: | r-release (arm64):carts_0.1.0.tgz, r-oldrel (arm64):carts_0.1.0.tgz, r-release (x86_64):carts_0.1.0.tgz, r-oldrel (x86_64):carts_0.1.0.tgz |
Please use the canonical formhttps://CRAN.R-project.org/package=cartsto link to this page.