pmxNODE: Application of NODEs in 'Monolix', 'NONMEM', and 'nlmixr2'
An easy-to-use tool for implementing Neural Ordinary Differential Equations (NODEs) in pharmacometric software such as 'Monolix', 'NONMEM', and 'nlmixr2', see Bräm et al. (2024) <doi:10.1007/s10928-023-09886-4> and Bräm et al. (2025) <doi:10.1002/psp4.13265>. The main functionality is to automatically generate structural model code describing computations within a neural network. Additionally, parameters and software settings can be initialized automatically. For using these additional functionalities with 'Monolix', 'pmxNODE' interfaces with 'MonolixSuite' via the 'lixoftConnectors' package. The 'lixoftConnectors' package is distributed with 'MonolixSuite' (<https://monolixsuite.slp-software.com/r-functions/2024R1/package-lixoftconnectors>) and is not available from public repositories.
| Version: | 0.1.0 |
| Imports: | tidyr,ggplot2,checkmate |
| Suggests: | rxode2,nlmixr2, lixoftConnectors,withr,testthat (≥3.0.0),knitr,rmarkdown |
| Published: | 2025-11-26 |
| DOI: | 10.32614/CRAN.package.pmxNODE |
| Author: | Dominic Bräm [aut, cre], Bernhard Steiert [ctb], Gilbert Koch [ctb], Matthew Fidler [ctb] |
| Maintainer: | Dominic Bräm <domi.braem at hotmail.com> |
| BugReports: | https://github.com/braemd/pmxNODE/issues |
| License: | GPL (≥ 3) |
| NeedsCompilation: | no |
| Citation: | pmxNODE citation info |
| Materials: | README |
| CRAN checks: | pmxNODE results |
Documentation:
| Reference manual: | pmxNODE.html ,pmxNODE.pdf |
| Vignettes: | pmxNODE in Monolix (source,R code) pmxNODE in NONMEM (source,R code) |
Downloads:
| Package source: | pmxNODE_0.1.0.tar.gz |
| Windows binaries: | r-devel:pmxNODE_0.1.0.zip, r-release:pmxNODE_0.1.0.zip, r-oldrel:pmxNODE_0.1.0.zip |
| macOS binaries: | r-release (arm64):pmxNODE_0.1.0.tgz, r-oldrel (arm64):pmxNODE_0.1.0.tgz, r-release (x86_64):pmxNODE_0.1.0.tgz, r-oldrel (x86_64):pmxNODE_0.1.0.tgz |
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