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QuICSeedR

Overview

QuICSeedR is a comprehensive R package for analyzing and visualizingdata from fluorophore-assisted seed amplification assays, such asReal-Time Quaking-Induced Conversion (RT-QuIC) and fluorophore-assistedProtein Misfolding Cyclic Amplification (PMCA). This toolkit addresseslimitations in existing software by automating data processing,supporting large-scale analysis, and enabling comparative studies ofanalysis methods.

Features

• Automated data processing for RT-QuIC and PMCA assays
• Support for large-scale data analysis
• Comparative analysis of different methodologies
• Visualization tools for assay results
• Statistical analysis functions tailored for seed amplificationdata

Installation

You can install the development version of QuICSeedR from GitHubwith:

# install.packages("devtools")devtools::install_github("mancili/QuICSeedR")

Usage

For more detailed examples and function documentation, please referto the function help pages. The manuscript link will be added here onceit becomes available.

Requirements

• R (>= 4.1.0)

License

This R package for analyzing seed amplification assay data isavailable under a dual licensing model: it is freely available under theGNU General Public License v3.0 (GPL-3) for open-source use, and aseparate commercialLICENSEis offered for use cases that require additional rights or supportbeyond the scope of GPL-3.

Author

Manci Li, PhD

ORCID:0000-0003-3930-7117

Citation

If you use QuICSeedR in your research, please cite it as follows:

Li, M. (2024). QuICSeedR: Data analysis for fluorophore-assisted seed amplification assays. R package version 0.1.2. https://github.com/mancili/QuICSeedR

Contact

For questions and feedback, please contact Dr. Manci Li atli000021@umn.edu.