Provides comprehensive tools for blinded sample size re-estimation (BSSR) in two-arm clinical trials with binary endpoints. Unlike traditional fixed-sample designs, BSSR allows adaptive sample size adjustments during trials while maintaining statistical integrity and study blinding. Implements five exact statistical tests: Pearson chi-squared, Fisher exact, Fisher mid-p, Z-pooled exact unconditional, and Boschloo exact unconditional tests. Supports restricted, unrestricted, and weighted BSSR approaches with exact Type I error control. Statistical methods based on Mehrotra et al. (2003) <doi:10.1111/1541-0420.00051> and Kieser (2020) <doi:10.1007/978-3-030-49528-2_21>.
| Version: | 1.0.2 |
| Depends: | R (≥ 3.5.0) |
| Imports: | fpCompare, stats |
| Suggests: | testthat (≥ 3.0.0),knitr,rmarkdown,dplyr,ggplot2,tibble,tidyr,Exact,exact2x2,microbenchmark |
| Published: | 2025-06-18 |
| DOI: | 10.32614/CRAN.package.bbssr |
| Author: | Gosuke Homma [aut, cre] |
| Maintainer: | Gosuke Homma <my.name.is.gosuke at gmail.com> |
| BugReports: | https://github.com/gosukehommaEX/bbssr/issues |
| License: | MIT + fileLICENSE |
| URL: | https://github.com/gosukehommaEX/bbssr |
| NeedsCompilation: | no |
| Materials: | NEWS |
| CRAN checks: | bbssr results |
| Package source: | bbssr_1.0.2.tar.gz |
| Windows binaries: | r-devel:bbssr_1.0.2.zip, r-release:bbssr_1.0.2.zip, r-oldrel:bbssr_1.0.2.zip |
| macOS binaries: | r-release (arm64):bbssr_1.0.2.tgz, r-oldrel (arm64):bbssr_1.0.2.tgz, r-release (x86_64):bbssr_1.0.2.tgz, r-oldrel (x86_64):bbssr_1.0.2.tgz |
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