Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
| Version: | 5.0.2 |
| Depends: | nlmixr2data, R (≥ 4.0) |
| Imports: | backports,checkmate,cli, graphics,knitr,lbfgsb3c,lotri,magrittr,Matrix, methods,minqa,n1qn1 (≥ 6.0.1-12),nlme,Rcpp,rex,rxode2 (≥ 5.0.0), stats,symengine, utils |
| LinkingTo: | BH,n1qn1 (≥ 6.0.1-12),lbfgsb3c (≥ 2024-3.5),lotri (≥0.5.0),Rcpp,RcppArmadillo (≥ 0.11.2.3.1),RcppEigen,rxode2 (> 4.0.3) |
| Suggests: | broom.mixed,crayon,data.table,devtools,digest,dplyr (≥1.1.0),generics,nloptr,qs2,qs,sys,testthat,tibble,withr,xgxr,sfsmisc,minpack.lm,remotes,fastGHQuad |
| Published: | 2025-11-28 |
| DOI: | 10.32614/CRAN.package.nlmixr2est |
| Author: | Matthew Fidler [aut, cre], Yuan Xiong [aut], Rik Schoemaker [aut], Justin Wilkins [aut], Wenping Wang [aut], Robert Leary [ctb], Mason McComb [ctb], Vipul Mann [aut], Mirjam Trame [ctb], Mahmoud Abdelwahab [ctb], Teun Post [ctb], Richard Hooijmaijers [aut], Hadley Wickham [ctb], Dirk Eddelbuettel [cph], Johannes Pfeifer [ctb], Robert B. Schnabel [ctb], Elizabeth Eskow [ctb], Emmanuelle Comets [ctb], Audrey Lavenu [ctb], Marc Lavielle [ctb], David Ardia [cph], Katharine Mullen [cph], Ben Goodrich [ctb] |
| Maintainer: | Matthew Fidler <matthew.fidler at gmail.com> |
| License: | GPL (≥ 3) |
| URL: | https://github.com/nlmixr2/nlmixr2est,https://nlmixr2.github.io/nlmixr2est/ |
| NeedsCompilation: | yes |
| Language: | en-US |
| Citation: | nlmixr2est citation info |
| Materials: | NEWS |
| CRAN checks: | nlmixr2est results |