PMAPscore: Identify Prognosis-Related Pathways Altered by Somatic Mutation
We innovatively defined a pathway mutation accumulate perturbation score (PMAPscore) to reflect the position and the cumulative effect of the genetic mutations at the pathway level. Based on the PMAPscore of pathways, identified prognosis-related pathways altered by somatic mutation and predict immunotherapy efficacy by constructing a multiple-pathway-based risk model (Tarca, Adi Laurentiu et al (2008) <doi:10.1093/bioinformatics/btn577>).
| Version: | 0.1.1 |
| Depends: | R (≥ 4.1.0) |
| Imports: | base,clusterProfiler,glmnet, graphics, grDevices,maftools,org.Hs.eg.db,pROC, stats,survival,survminer, utils |
| Suggests: | knitr,rmarkdown |
| Published: | 2022-04-12 |
| DOI: | 10.32614/CRAN.package.PMAPscore |
| Author: | Junwei Han [aut, cre, cph], Yalan He [aut], Xiangmei Li [aut] |
| Maintainer: | Junwei Han <hanjunwei1981 at 163.com> |
| License: | GPL-2 |GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: | no |
| CRAN checks: | PMAPscore results |
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