karyotapR enables analysis of DNA copy number (aneuploidy) using dataproduced by the KaryoTap method. Users can easily parse, manipulate, andvisualize datasets produced from the automated ‘Tapestri Pipeline’, withsupport for normalization, clustering, and copy number calling.Functions are also available to deconvolute multiplexed samples bygenotype and parsing barcoded reads from exogenous lentiviralconstructs.
KaryoTap combines custom genome-wide targeted DNA sequencing panelsfor the Mission Bio Tapestri system with a Gaussian mixture modelframework for calling copy number.
Mays JC et al., 2023.KaryoTap Enables Aneuploidy Detection inThousands of Single Human Cells.https://www.biorxiv.org/content/10.1101/2023.09.08.555746v1.
You can install the current stable version of karyotapR fromCRAN with:
install.packages('karyotapR')You can install the development version of karyotapR fromGitHub with:
# install.packages("devtools")devtools::install_github("joeymays/karyotapR")For details on the workflow, see theGettingStarted guide, articles on this site, and the packagereference/documentation.
