DRviaSPCN: Drug Repurposing in Cancer via a Subpathway Crosstalk Network
A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.
| Version: | 0.1.5 |
| Depends: | R (≥ 3.6) |
| Imports: | GSVA,clusterProfiler, graphics,igraph,pheatmap, stats |
| Suggests: | rmarkdown,knitr,DT |
| Published: | 2025-01-09 |
| DOI: | 10.32614/CRAN.package.DRviaSPCN |
| Author: | Junwei Han [aut, cre, cph], Jiashuo Wu [aut] |
| Maintainer: | Junwei Han <hanjunwei1981 at 163.com> |
| License: | GPL-2 |GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: | no |
| CRAN checks: | DRviaSPCN results |
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