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twoCoprimary: Sample Size and Power Calculation for Two Co-Primary Endpoints

Comprehensive functions to calculate sample size and power for clinical trials with two co-primary endpoints. The package supports five endpoint combinations: two continuous endpoints (Sozu et al. 2011 <doi:10.1080/10543406.2011.551329>), two binary endpoints using asymptotic methods (Sozu et al. 2010 <doi:10.1002/sim.3972>) and exact methods (Homma and Yoshida 2025 <doi:10.1177/09622802251368697>), mixed continuous and binary endpoints (Sozu et al. 2012 <doi:10.1002/bimj.201100221>), and mixed count and continuous endpoints (Homma and Yoshida 2024 <doi:10.1002/pst.2337>). All methods appropriately account for correlation between endpoints and provide both sample size and power calculation capabilities.

Version:	1.0.0
Depends:	R (≥ 3.5.0)
Imports:	mvtnorm,pbivnorm,fpCompare, stats
Suggests:	dplyr,knitr,rmarkdown,testthat (≥ 3.0.0),tibble,tidyr,readr
Published:	2025-11-21
DOI:	10.32614/CRAN.package.twoCoprimary
Author:	Gosuke Homma [aut, cre]
Maintainer:	Gosuke Homma <my.name.is.gosuke at gmail.com>
BugReports:	https://github.com/gosukehommaEX/twoCoprimary/issues
License:	MIT + fileLICENSE
URL:	https://gosukehommaex.github.io/twoCoprimary/,https://github.com/gosukehommaEX/twoCoprimary
NeedsCompilation:	no
Language:	en-US
Materials:	README,NEWS
CRAN checks:	twoCoprimary results

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