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Xpose 4

by Andrew C. Hooker, Mats O. Karlsson and E. Niclas Jonsson

Introduction

Xpose 4 is a collection of functions to be used as a model buildingaid for nonlinear mixed-effects (population) analysis using NONMEM. Itfacilitates data set checkout, exploration and visualization, modeldiagnostics, candidate covariate identification and modelcomparison.

Installation

To install xpose you will need R (>= version 2.2.0).
To install Xpose in R use one of the following methods:

• latest stable release – From CRAN. Write at the R commandline:

  install.packages("xpose4")

• Latest development version – from Github. Note that the commandbelow installs the “master” (development) branch; if you want therelease branch from Github addref="release" to theinstall_github() call.

  # install.packages("devtools")devtools::install_github("UUPharmacometrics/xpose4")

Running Xpose 4

Start R and load xpose:

library(xpose4)#> Loading required package: lattice

To use the classic menu system, type at the R command prompt:

xpose4()

Each function is independently available from the command line, oncethe Xpose library is loaded.

First we create a set of files from a NONMEM run

cur.files<-dir()# current files in temp directorysimprazExample()# write files from an example NONMEM runnew.files<-dir()[!(dir()%in% cur.files)]# the new files created by simprazExample

Then we can import our files to Xpose

xpdb<-xpose.data(1)

Display goodness-of-fit plots:

basic.gof(xpdb)

Clean up files that were created to show these examples:

unlink(new.files)

More help is available in the online documentation, which can befound by typing (for example)?xpose4 at the R commandline.

Don’t Panic

Andrew Hooker (andrew.hooker at farmaci.uu.se) should be able to getyou an answer if you run into trouble. The websitehttps://uupharmacometrics.github.io/xpose4/ should alsobe of help.

Release Schedule

Bugfix releases will be released regularly, fixing any problems thatare found.

License

Xpose 4 is free software: you can redistribute it and/or modify itunder the terms of the GNU Lesser General Public License as published bythe Free Software Foundation, either version 3 of the License, or (atyour option) any later version.

This program is distributed in the hope that it will be useful, butWITHOUT ANY WARRANTY; without even the implied warranty ofMERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU LesserGeneral Public License for more detailshttps://www.gnu.org/licenses/.

Known Bugs

None at present, but there will certainly be a few. Report them athttps://github.com/UUPharmacometrics/xpose4/issues.