Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
| Version: | 5.0.0 |
| Imports: | cli (≥ 1.0.0),crayon (≥ 1.3.4),dplyr (≥ 0.7.4),purrr (≥0.2.4),rstudioapi (≥ 0.7),nlmixr2est (≥ 5.0.0),nlmixr2extra (≥ 5.0.0),rxode2 (≥ 5.0.0),lotri (≥ 0.4.3),nlmixr2plot (≥ 5.0.0),tibble,magrittr |
| Suggests: | rmarkdown,knitr,devtools,ggplot2,testthat,n1qn1,withr |
| Published: | 2025-11-30 |
| DOI: | 10.32614/CRAN.package.nlmixr2 |
| Author: | Matthew Fidler [aut, cre], Anne Keunecke [ctb], Rik Schoemaker [ctb], Justin Wilkins [ctb], Wenping Wang [ctb], Mirjam Trame [ctb], John Harrold [ctb], Bill Denney [ctb], Theodoros Papathanasiou [ctb], Richard Hooijmaijers [ctb], Michael Wayne Kearney [ctb] |
| Maintainer: | Matthew Fidler <matthew.fidler at gmail.com> |
| BugReports: | https://github.com/nlmixr2/nlmixr2/issues/ |
| License: | GPL (≥ 3) |
| URL: | https://nlmixr2.org/,https://github.com/nlmixr2/nlmixr2/ |
| NeedsCompilation: | no |
| Citation: | nlmixr2 citation info |
| Materials: | README,NEWS |
| In views: | DifferentialEquations,HighPerformanceComputing,MixedModels,Pharmacokinetics |
| CRAN checks: | nlmixr2 results |