The tcplfit2 R package performs basic concentration-response curve fitting. The original tcplFit() function in the tcpl R package performed basic concentration-response curvefitting to 3 models. With tcplfit2, the core tcpl concentration-response functionality has been expanded to process diverse high-throughput screen (HTS) data generated at the US Environmental Protection Agency, including targeted ToxCast, high-throughput transcriptomics (HTTr) and high-throughput phenotypic profiling (HTPP). tcplfit2 can be used independently to support analysis for diverse chemical screening efforts.
| Version: | 0.1.9 |
| Depends: | R (≥ 3.5.0) |
| Imports: | stats, methods,numDeriv,RColorBrewer,stringr,reshape2,ggplot2 (≥ 3.5.0) |
| Suggests: | knitr,rmarkdown,stringi,DT,data.table,tcpl,prettydoc,testthat (≥ 3.0.0),here,htmlTable,tidyr,dplyr,gridExtra,rmdformats |
| Published: | 2025-07-23 |
| DOI: | 10.32614/CRAN.package.tcplfit2 |
| Author: | Thomas Sheffield [aut], Jason Brown [ctb], Sarah E. Davidson-Fritz [ctb], Madison Feshuk [ctb, cre], Lindsay Knupp [ctb], Zhihui Zhao [ctb], Richard S Judson [ctb], Katie Paul Friedman [ctb] |
| Maintainer: | Madison Feshuk <feshuk.madison at epa.gov> |
| BugReports: | https://github.com/USEPA/CompTox-ToxCast-tcplFit2/issues |
| License: | MIT + fileLICENSE |
| URL: | https://github.com/USEPA/CompTox-ToxCast-tcplFit2 |
| NeedsCompilation: | no |
| Materials: | README,NEWS |
| CRAN checks: | tcplfit2 results |