Bayesian logistic regression model with optional EXchangeability-NonEXchangeability parameter modelling for flexible borrowing from historical or concurrent data-sources. The safety model can guide dose-escalation decisions for adaptive oncology Phase I dose-escalation trials which involve an arbitrary number of drugs. Please refer to Neuenschwander et al. (2008) <doi:10.1002/sim.3230> and Neuenschwander et al. (2016) <doi:10.1080/19466315.2016.1174149> for details on the methodology.
| Version: | 0.9-3 |
| Depends: | R (≥ 3.5.0),RBesT (≥ 1.8-0) |
| Imports: | methods,Rcpp (≥ 0.12.0),RcppParallel (≥ 5.0.1),rstan (≥2.32.0),rstantools (≥ 2.4.0),posterior (≥ 1.5.0),assertthat (≥ 0.2.1),checkmate,Formula,bayesplot (≥1.4.0),ggplot2 (≥ 3.0.0),dplyr (≥ 1.1.0),tibble,tidyr (≥1.0.0),abind,scales,rlang (≥ 0.3.0),tidyselect, utils, stats,matrixStats,brms,lifecycle, grDevices |
| LinkingTo: | BH (≥ 1.75.0),Rcpp (≥ 0.12.0),RcppEigen (≥ 0.3.3.3.0),RcppParallel (≥ 5.0.1),rstan (≥ 2.32.0),StanHeaders (≥2.32.0) |
| Suggests: | rmarkdown,knitr,testthat (≥ 2.0.0),withr,mvtnorm,vdiffr, cmdstanr (≥ 0.4.0),ragg |
| Published: | 2025-04-25 |
| DOI: | 10.32614/CRAN.package.OncoBayes2 |
| Author: | Novartis Pharma AG [cph], Sebastian Weber [aut, cre], Lukas A. Widmer [aut], Andrew Bean [aut], Trustees of Columbia University [cph] (R/stanmodels.R, configure, configure.win) |
| Maintainer: | Sebastian Weber <sebastian.weber at novartis.com> |
| License: | GPL (≥ 3) |
| NeedsCompilation: | yes |
| SystemRequirements: | GNU make, pandoc (>= 1.12.3), pngquant, C++17 |
| Additional_repositories: | https://mc-stan.org/r-packages/ |
| Materials: | NEWS |
| In views: | ClinicalTrials |
| CRAN checks: | OncoBayes2 results |
| Reference manual: | OncoBayes2.html ,OncoBayes2.pdf |
| Vignettes: | Guiding Oncology Dose-Escalation Trials (source,R code) MAP approach to historical data (source,R code) |
| Package source: | OncoBayes2_0.9-3.tar.gz |
| Windows binaries: | r-devel:OncoBayes2_0.9-3.zip, r-release:OncoBayes2_0.9-3.zip, r-oldrel:OncoBayes2_0.9-3.zip |
| macOS binaries: | r-release (arm64):OncoBayes2_0.9-3.tgz, r-oldrel (arm64):OncoBayes2_0.9-3.tgz, r-release (x86_64):OncoBayes2_0.9-3.tgz, r-oldrel (x86_64):OncoBayes2_0.9-3.tgz |
| Old sources: | OncoBayes2 archive |
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