invitroTKstats: In Vitro Toxicokinetic Data Processing and Analysis Pipeline
A set of tools for processing and analyzing in vitro toxicokinetic measurements in a standardized and reproducible pipeline. The package was developed to perform frequentist and Bayesian estimation on a variety of in vitro toxicokinetic measurements including – but not limited to – chemical fraction unbound in the presence of plasma (f_up), intrinsic hepatic clearance (Clint, uL/min/million hepatocytes), and membrane permeability for oral absorption (Caco2). The methods provided by the package were described in Wambaugh et al. (2019) <doi:10.1093/toxsci/kfz205>.
| Version: | 0.0.13 |
| Depends: | R (≥ 3.5.0) |
| Imports: | runjags, parallel,readxl,coda,ggplot2,scales, stats4,Rdpack, methods, stats, utils,dplyr,rlang |
| Suggests: | knitr,R.rsp,tidyverse,gridExtra,gridtext,flextable,rmarkdown,magrittr,stringr |
| Published: | 2025-08-19 |
| DOI: | 10.32614/CRAN.package.invitroTKstats |
| Author: | John Wambaugh [aut], Sarah E. Davidson-Fritz [aut, cre], Lindsay Knupp [ctb], Barbara A. Wetmore [ctb], Zhao Zhihui [ctb], Chantel Nicolas [ctb], Anna Kreutz [ctb], U.S. Federal Government [cph] (Copyright holder of this package) |
| Maintainer: | Sarah E. Davidson-Fritz <davidsonfritz.sarah at epa.gov> |
| BugReports: | https://github.com/USEPA/invitroTKstats/issues |
| License: | MIT + fileLICENSE |
| URL: | https://github.com/USEPA/invitroTKstats |
| NeedsCompilation: | no |
| Materials: | README,NEWS |
| CRAN checks: | invitroTKstats results |
Documentation:
| Reference manual: | invitroTKstats.html ,invitroTKstats.pdf |
| Vignettes: | Appendix (source,R code) Caco-2 (source,R code) Clint (source,R code) data_guide_and_LO (source,R code) Fup RED (source,R code) Fup UC (source,R code) Plotting Functions (source,R code) |
Downloads:
| Package source: | invitroTKstats_0.0.13.tar.gz |
| Windows binaries: | r-devel:invitroTKstats_0.0.13.zip, r-release:invitroTKstats_0.0.13.zip, r-oldrel:invitroTKstats_0.0.13.zip |
| macOS binaries: | r-release (arm64):invitroTKstats_0.0.13.tgz, r-oldrel (arm64):invitroTKstats_0.0.13.tgz, r-release (x86_64):invitroTKstats_0.0.13.tgz, r-oldrel (x86_64):invitroTKstats_0.0.13.tgz |
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