escalation: A Modular Approach to Dose-Finding Clinical Trials
Methods for working with dose-finding clinical trials. We provide implementations of many dose-finding clinical trial designs, including the continual reassessment method (CRM) by O'Quigley et al. (1990) <doi:10.2307/2531628>, the toxicity probability interval (TPI) design by Ji et al. (2007) <doi:10.1177/1740774507079442>, the modified TPI (mTPI) design by Ji et al. (2010) <doi:10.1177/1740774510382799>, the Bayesian optimal interval design (BOIN) by Liu & Yuan (2015) <doi:10.1111/rssc.12089>, EffTox by Thall & Cook (2004) <doi:10.1111/j.0006-341X.2004.00218.x>; the design of Wages & Tait (2015) <doi:10.1080/10543406.2014.920873>, and the 3+3 described by Korn et al. (1994) <doi:10.1002/sim.4780131802>. All designs are implemented with a common interface. We also offer optional additional classes to tailor the behaviour of all designs, including avoiding skipping doses, stopping after n patients have been treated at the recommended dose, stopping when a toxicity condition is met, or demanding that n patients are treated before stopping is allowed. By daisy-chaining together these classes using the pipe operator from 'magrittr', it is simple to tailor the behaviour of a dose-finding design so it behaves how the trialist wants. Having provided a flexible interface for specifying designs, we then provide functions to run simulations and calculate dose-paths for future cohorts of patients.
| Version: | 0.2.3 |
| Depends: | magrittr |
| Imports: | dplyr,tidyr (≥ 1.0),tidyselect,stringr,purrr,tibble,ggplot2,gtools,dfcrm,BOIN,trialr (≥ 0.1.5),DiagrammeR,RColorBrewer,viridis,binom,R6,mvtnorm, graphics,Iso,testthat |
| Suggests: | knitr,rmarkdown,covr |
| Published: | 2025-10-08 |
| DOI: | 10.32614/CRAN.package.escalation |
| Author: | Kristian Brock [aut, cre], Daniel Slade [aut], Michael Sweeting [aut], Conor Norris [ctb], Bharat Bhushan [ctb] |
| Maintainer: | Kristian Brock <kristian.brock at gmail.com> |
| BugReports: | https://github.com/brockk/escalation/issues |
| License: | GPL (≥ 3) |
| URL: | https://brockk.github.io/escalation/,https://github.com/brockk/escalation |
| NeedsCompilation: | no |
| Materials: | README,NEWS |
| In views: | ClinicalTrials |
| CRAN checks: | escalation results |
Documentation:
Downloads:
| Package source: | escalation_0.2.3.tar.gz |
| Windows binaries: | r-devel:escalation_0.2.3.zip, r-release:escalation_0.2.3.zip, r-oldrel:escalation_0.2.3.zip |
| macOS binaries: | r-release (arm64):escalation_0.2.3.tgz, r-oldrel (arm64):escalation_0.2.3.tgz, r-release (x86_64):escalation_0.2.3.tgz, r-oldrel (x86_64):escalation_0.2.3.tgz |
| Old sources: | escalation archive |
Linking:
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