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pocrm: Dose Finding in Drug Combination Phase I Trials Using PO-CRM

Provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) of Wages, Conaway and O'Quigley (2011) <doi:10.1177/1740774511408748> for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.

Version:	0.13
Depends:	dfcrm,nnet
Imports:	stats
Published:	2021-09-08
DOI:	10.32614/CRAN.package.pocrm
Author:	Nolan A. Wages
Maintainer:	"Brewer, Ben (arb5mt)" <arb5mt at virginia.edu>
License:	GPL-2
NeedsCompilation:	no
In views:	ClinicalTrials
CRAN checks:	pocrm results

Documentation:

Reference manual:

pocrm.html ,pocrm.pdf

Downloads:

Package source:	pocrm_0.13.tar.gz
Windows binaries:	r-devel:pocrm_0.13.zip, r-release:pocrm_0.13.zip, r-oldrel:pocrm_0.13.zip
macOS binaries:	r-release (arm64):pocrm_0.13.tgz, r-oldrel (arm64):pocrm_0.13.tgz, r-release (x86_64):pocrm_0.13.tgz, r-oldrel (x86_64):pocrm_0.13.tgz
Old sources:	pocrm archive

Linking:

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