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TrialSimulator: Clinical Trial Simulator

Simulate phase II and/or phase III clinical trials. It supports various types of endpoints and adaptive strategies. Tools for carrying out graphical testing procedure and combination test under group sequential design are also provided.

Version:	1.3.0
Depends:	R (≥ 4.1.0)
Imports:	base64enc,dplyr,emmeans,ggplot2,gMCPLite,htmltools,mvtnorm,R6,rlang,rpact,rstudioapi,survival, utils
Suggests:	DoseFinding,graphicalMCP,kableExtra,knitr,rmarkdown,simdata,survminer,testthat (≥ 3.0.0)
Published:	2025-09-26
DOI:	10.32614/CRAN.package.TrialSimulator
Author:	Han Zhang [cre, aut]
Maintainer:	Han Zhang <zhangh.ustc at gmail.com>
BugReports:	https://github.com/zhangh12/TrialSimulator/issues
License:	MIT + fileLICENSE
URL:	https://zhangh12.github.io/TrialSimulator/
NeedsCompilation:	no
Materials:	README,NEWS
CRAN checks:	TrialSimulator results

Documentation:

Reference manual:

TrialSimulator.html ,TrialSimulator.pdf

Vignettes:

Specify Actions to Execute at Trial Milestones (source,R code)
An Example of Simulating a Trial with Adaptive Design (source,R code)
Condition System for Triggering Milestones in a Trial (source,R code)
Define and Summarize Arms in Clinical Trials (source,R code)
Define Longitudinal Endpoints (source,R code)
Define Non-Time-to-Event Endpoints (source,R code)
Define Time-to-Event Endpoints (source,R code)
An Example of Fixed Design with Two Correlated Endpoints (source,R code)
Designs with Response-Adaptive Randomization (source,R code)
Simulate Correlated Progression-Free Survival and Overall Survival as Endpoints (source,R code)
Wrapper Functions of Common Statistical Methods in TrialSimulator (source,R code)

Downloads:

Package source:	TrialSimulator_1.3.0.tar.gz
Windows binaries:	r-devel:TrialSimulator_1.3.0.zip, r-release:TrialSimulator_1.3.0.zip, r-oldrel:TrialSimulator_1.3.0.zip
macOS binaries:	r-release (arm64):TrialSimulator_1.3.0.tgz, r-oldrel (arm64):TrialSimulator_1.3.0.tgz, r-release (x86_64):TrialSimulator_1.3.0.tgz, r-oldrel (x86_64):TrialSimulator_1.3.0.tgz
Old sources:	TrialSimulator archive

Linking:

Please use the canonical formhttps://CRAN.R-project.org/package=TrialSimulatorto link to this page.