The DoseFinding package provides functions for the design and analysis of dose-finding experiments (with focus on pharmaceutical Phase II clinical trials). It provides functions for: multiple contrast tests, fitting non-linear dose-response models (using Bayesian and non-Bayesian estimation), calculating optimal designs and an implementation of the MCPMod methodology (Pinheiro et al. (2014) <doi:10.1002/sim.6052>).
| Version: | 1.4-1 |
| Imports: | ggplot2,lattice,mvtnorm |
| Suggests: | emmeans,numDeriv,Rsolnp,quadprog, parallel,mmrm,multcomp,knitr,rmarkdown,MASS,testthat (≥ 3.0.0),tibble,RBesT,nlme,dplyr,tidyr |
| Published: | 2025-07-09 |
| DOI: | 10.32614/CRAN.package.DoseFinding |
| Author: | Bjoern Bornkamp [aut], Jose Pinheiro [aut], Frank Bretz [aut], Ludger Sandig [aut], Marius Thomas [aut, cre], Daniel Sabanes Bove [aut], Novartis Pharma AG [cph, fnd] |
| Maintainer: | Marius Thomas <marius.thomas at novartis.com> |
| BugReports: | https://github.com/openpharma/DoseFinding/issues |
| License: | GPL-3 |
| URL: | https://github.com/openpharma/DoseFinding,https://openpharma.github.io/DoseFinding/ |
| NeedsCompilation: | yes |
| Materials: | README,NEWS |
| In views: | ClinicalTrials,ExperimentalDesign |
| CRAN checks: | DoseFinding results |