Facilities for running simulations from ordinary differential equation ('ODE') models, such as pharmacometrics and other compartmental models. A compilation manager translates the ODE model into C, compiles it, and dynamically loads the object code into R for improved computational efficiency. An event table object facilitates the specification of complex dosing regimens (optional) and sampling schedules. NB: The use of this package requires both C and Fortran compilers, for details on their use with R please see Section 6.3, Appendix A, and Appendix D in the "R Administration and Installation" manual. Also the code is mostly released under GPL. The 'VODE' and 'LSODA' are in the public domain. The information is available in the inst/COPYRIGHTS.
| Version: | 5.0.1 |
| Depends: | R (≥ 4.0.0) |
| Imports: | PreciseSums (≥ 0.7),Rcpp (≥ 0.12.3),backports,cli (≥2.0.0),checkmate,ggplot2 (≥ 3.4.0),inline,lotri (≥1.0.2),magrittr,memoise, methods,rex,sys, tools, utils,dparser (≥ 1.3.1-12),rxode2ll (≥ 2.0.9),data.table (≥1.12.4),qs2 |
| LinkingTo: | sitmo,lotri (≥ 1.0.0),PreciseSums (≥ 0.7),Rcpp,RcppArmadillo (≥ 0.9.300.2.0),BH,RcppParallel,RcppEigen (≥0.3.3.9.2),StanHeaders (≥ 2.21.0.7),dparser (≥ 1.3.1-12) |
| Suggests: | Matrix,DT,covr,crayon,curl,digest,dplyr (≥ 0.8.0),ggrepel,gridExtra,htmltools,knitr,learnr,microbenchmark,nlme,remotes,rlang,rmarkdown,scales,shiny,stringi,symengine,testthat,tidyr,usethis,withr,xgxr,pillar,tibble,units (≥ 0.6-0),rsconnect,devtools,patchwork,nlmixr2data,lifecycle,kableExtra,pmxTools,qs,rootSolve |
| Published: | 2025-12-09 |
| DOI: | 10.32614/CRAN.package.rxode2 |
| Author: | Matthew L. Fidler [aut, cre], Wenping Wang [aut], Alan Hindmarsh [ctb], Arun Srinivasan [ctb], Awad H. Al-Mohy [ctb], Bill Denney [ctb], Cleve Moler [ctb], David Cooley [ctb], Drew Schmidt [ctb], Ernst Hairer [ctb], Gabriel Staples [ctb], Gerhard Wanner [ctb], Gilbert Stewart [ctb], Goro Fuji [ctb], Hadley Wickham [ctb], Igor Kushnir [ctb], Jack Dongarra [ctb], Jim Bunch [ctb], Kevin Ushey [ctb], Linda Petzold [ctb], Martin Maechler [ctb], Matt Dowle [ctb], Matteo Fasiolo [ctb], Melissa Hallow [aut], Michel Lang [ctb], Morwenn [ctb], Nicholas J. Higham [ctb], Omar Elashkar [ctb], Richard Upton [ctb], Roger B. Sidje [ctb], Simon Frost [ctb], Yu Feng [ctb], Zufar Mulyukov [ctb] |
| Maintainer: | Matthew L. Fidler <matthew.fidler at gmail.com> |
| BugReports: | https://github.com/nlmixr2/rxode2/issues/ |
| License: | GPL (≥ 3) |
| Copyright: | see fileCOPYRIGHTS |
| URL: | https://nlmixr2.github.io/rxode2/,https://github.com/nlmixr2/rxode2/ |
| NeedsCompilation: | yes |
| Language: | en-US |
| Citation: | rxode2 citation info |
| Materials: | README,NEWS |
| In views: | DifferentialEquations,HighPerformanceComputing,MixedModels,Pharmacokinetics |
| CRAN checks: | rxode2 results |