LTFHPlus: Implementation of LT-FH++
Implementation of LT-FH++, an extension of the liability threshold family history (LT-FH) model. LT-FH++ uses a Gibbs sampler for sampling from the truncated multivariate normal distribution and allows for flexible family structures. LT-FH++ was first described in Pedersen, Emil M., et al. (2022) <doi:10.1016/j.ajhg.2022.01.009> as an extension to LT-FH with more flexible family structures, and again as the age-dependent liability threshold (ADuLT) model Pedersen, Emil M., et al. (2023) <https://www.nature.com/articles/s41467-023-41210-z> as an alternative to traditional time-to-event genome-wide association studies, where family history was not considered.
| Version: | 2.2.0 |
| Imports: | batchmeans,dplyr,future.apply,future,purrr,Rcpp,rlang, stats,stringr,tibble,tmvtnorm,tidyselect,igraph,xgboost,tidyr,ggplot2 |
| LinkingTo: | Rcpp |
| Suggests: | MASS,knitr,rmarkdown,kinship2,testthat |
| Published: | 2025-11-17 |
| DOI: | 10.32614/CRAN.package.LTFHPlus |
| Author: | Emil Michael Pedersen [aut, cre], Florian Privé [aut, ths], Bjarni Jóhann Vilhjálmsson [ths], Esben Agerbo [ths], Jette Steinbach [aut], Lucas Rasmussen [ctb] |
| Maintainer: | Emil Michael Pedersen <emp at ph.au.dk> |
| BugReports: | https://github.com/EmilMiP/LTFHPlus/issues |
| License: | GPL-3 |
| URL: | https://emilmip.github.io/LTFHPlus/,https://github.com/EmilMiP/LTFHPlus |
| NeedsCompilation: | yes |
| Language: | en-GB |
| Materials: | README,NEWS |
| CRAN checks: | LTFHPlus results |
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