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httkexamples: High-Throughput Toxicokinetics Examples

High throughput toxicokinetics ("HTTK") is the combination of 1) chemical-specific in vitro measurements or in silico predictions and 2) generic mathematical models, to predict absorption, distribution, metabolism, and excretion by the body. HTTK methods have been described by Pearce et al. (2017) (<doi:10.18637/jss.v079.i04>) and Breen et al. (2021) (<doi:10.1080/17425255.2021.1935867>). Here we provide examples (vignettes) applying HTTK to solve various problems in bioinformatics, toxicology, and exposure science. In accordance with Davidson-Fritz et al. (2025) (<doi:10.1371/journal.pone.0321321>), whenever a new HTTK model is developed, the code to generate the figures evaluating that model is added as a new vignettte.

Version:	0.0.1
Depends:	R (≥ 2.10)
Imports:	httk,rmarkdown,knitr,Rdpack
Suggests:	dplyr,tidyverse,xlsx,Metrics,ggplot2,ggforce,ggpubr,ggrepel,viridis,ggpubr, grid,ggh4x,readr,ggforce,tidyr,stringr,pracma,cgwtools,openxlsx,ggstar,latex2exp,smatr,reshape,gdata,censReg,gmodels,gplots,scales,colorspace,gridExtra,rvcheck
Published:	2025-12-10
DOI:	10.32614/CRAN.package.httkexamples
Author:	John Wambaugh [aut, cre], Robert Pearce [aut], Caroline Ring [aut], Greg Honda [aut], Matt Linakis [aut], Dustin Kapraun [aut], Kimberly Truong [aut], Meredith Scherer [aut], Annabel Meade [aut], Celia Schacht [aut], Elaina Kenyon [ctb]
Maintainer:	John Wambaugh <john.wambaugh at UL.org>
License:	MIT + fileLICENSE
URL:	https://chemicalinsights.ul.org/
NeedsCompilation:	no
Citation:	httkexamples citation info
Materials:	README,NEWS
CRAN checks:	httkexamples results

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