The package offers tests for trajectory presence and heterogeneity onmultivariate data. Two statistical methods (Tenha and Song, 2022) areimplemented. The tree dimension test quantifies the statistical evidencefor trajectory presence. The subset specificity measure summarizespattern heterogeneity using the minimum subtree cover. There is no usertunable parameters for either method. Examples are included toillustrate how to use the methods on single-cell data for studying geneand pathway expression dynamics and pathway expression specificity.
install.packages("DimensionTreeTest")See the package vignette.
Tenha L, Song M (2022). “Inference of trajectory presence by treedimension and subset specificity by subtree cover.”PLOSComputational Biology,18(2), e1009829. doi:10.1371/journal.pcbi.1009829 (URL:https://doi.org/10.1371/journal.pcbi.1009829).