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brms.mmrm: Bayesian MMRMs using 'brms'

The mixed model for repeated measures (MMRM) is a popular model for longitudinal clinical trial data with continuous endpoints, and 'brms' is a powerful and versatile package for fitting Bayesian regression models. The 'brms.mmrm' R package leverages 'brms' to run MMRMs, and it supports a simplified interfaced to reduce difficulty and align with the best practices of the life sciences. References: Bürkner (2017) <doi:10.18637/jss.v080.i01>, Mallinckrodt (2008) <doi:10.1177/009286150804200402>.

Version:1.1.1
Depends:R (≥ 4.0.0)
Imports:brms (≥ 2.19.0),dplyr,ggplot2,ggridges,MASS,posterior,purrr,rlang, stats,tibble,tidyr,tidyselect,trialr, utils,zoo
Suggests:BH,emmeans (≥ 1.8.7),fst,gt,gtsummary,knitr (≥ 1.30),markdown (≥ 1.1),mmrm, parallel,Rcpp,RcppEigen,RcppParallel,rmarkdown (≥ 2.4),rstan,StanHeaders,testthat (≥ 3.0.0)
Published:2024-10-02
DOI:10.32614/CRAN.package.brms.mmrm
Author:William Michael LandauORCID iD [aut, cre], Kevin KunzmannORCID iD [aut], Yoni Sidi [aut], Christian StockORCID iD [aut], Eli Lilly and Company [cph, fnd], Boehringer Ingelheim Pharma GmbH & Co. KG [cph, fnd]
Maintainer:William Michael Landau <will.landau.oss at gmail.com>
BugReports:https://github.com/openpharma/brms.mmrm/issues
License:MIT + fileLICENSE
URL:https://openpharma.github.io/brms.mmrm/,https://github.com/openpharma/brms.mmrm
NeedsCompilation:no
Language:en-US
Materials:README,NEWS
In views:ClinicalTrials
CRAN checks:brms.mmrm results

Documentation:

Reference manual:brms.mmrm.html ,brms.mmrm.pdf
Vignettes:Informative prior archetypes (source)
BCVA data comparison between Bayesian and frequentist MMRMs (source)
FEV1 data comparison between Bayesian and frequentist MMRMs (source)
Inference (source,R code)
Model (source)
Simulation-based calibration checking (source,R code)
Simulation (source)
Subgroup analysis (source)
Usage (source)

Downloads:

Package source: brms.mmrm_1.1.1.tar.gz
Windows binaries: r-devel:brms.mmrm_1.1.1.zip, r-release:brms.mmrm_1.1.1.zip, r-oldrel:brms.mmrm_1.1.1.zip
macOS binaries: r-release (arm64):brms.mmrm_1.1.1.tgz, r-oldrel (arm64):brms.mmrm_1.1.1.tgz, r-release (x86_64):brms.mmrm_1.1.1.tgz, r-oldrel (x86_64):brms.mmrm_1.1.1.tgz
Old sources: brms.mmrm archive

Linking:

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