Fit Cox proportional hazards models containing both fixed and random effects. The random effects can have a general form, of which familial interactions (a "kinship" matrix) is a particular special case. Note that the simplest case of a mixed effects Cox model, i.e. a single random per-group intercept, is also called a "frailty" model. The approach is based on Ripatti and Palmgren, Biometrics 2002.
| Version: | 2.2-22 |
| Priority: | optional |
| Depends: | survival (≥ 2.36.14), methods,bdsmatrix (≥ 1.3), R (≥ 2.10) |
| Imports: | nlme,Matrix (≥ 1.0) |
| LinkingTo: | bdsmatrix |
| Suggests: | mvtnorm,kinship2 |
| Published: | 2024-08-23 |
| DOI: | 10.32614/CRAN.package.coxme |
| Author: | Terry M. Therneau [aut, cre] |
| Maintainer: | Terry M. Therneau <therneau.terry at mayo.edu> |
| License: | LGPL-2 |
| Copyright: | see fileCOPYRIGHTS |
| NeedsCompilation: | yes |
| Materials: | NEWS |
| In views: | Agriculture,MixedModels,Survival |
| CRAN checks: | coxme results |
| Reference manual: | coxme.html ,coxme.pdf |
| Vignettes: | Mixed Effects Cox Models (source,R code) Coxme and the Laplace Approximation (source,R code) The lmekin function (source,R code) Special Variance Structures (source,R code) |
| Package source: | coxme_2.2-22.tar.gz |
| Windows binaries: | r-devel:coxme_2.2-22.zip, r-release:coxme_2.2-22.zip, r-oldrel:coxme_2.2-22.zip |
| macOS binaries: | r-release (arm64):coxme_2.2-22.tgz, r-oldrel (arm64):coxme_2.2-22.tgz, r-release (x86_64):coxme_2.2-22.tgz, r-oldrel (x86_64):coxme_2.2-22.tgz |
| Old sources: | coxme archive |
| Reverse depends: | mlma |
| Reverse imports: | bigQF,EQUALSTATS,famSKATRC,highMLR,jstable,MAGNAMWAR,mlmm.gwas,multisite.accuracy,PenCoxFrail,spicyR,svycoxme |
| Reverse suggests: | AICcmodavg,car,finalfit,gap,injurytools,insight,modelbased,multcomp,parameters,tram,tramME |
| Reverse enhances: | emmeans,MuMIn |
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