replicateBE: Average Bioequivalence with Expanding Limits (ABEL)
Performs comparative bioavailability calculations for Average Bioequivalence with Expanding Limits (ABEL). Implemented are 'Method A' / 'Method B' and the detection of outliers. If the design allows, assessment of the empiric Type I Error and iteratively adjusting alpha to control the consumer risk. Average Bioequivalence - optionally with a tighter (narrow therapeutic index drugs) or wider acceptance range (South Africa: Cmax) - is implemented as well.
| Version: | 1.1.3 |
| Depends: | R (≥ 3.5.0) |
| Imports: | readxl (≥ 1.0.0),PowerTOST (≥ 1.5.3),lmerTest,nlme,pbkrtest, graphics, grDevices |
| Suggests: | knitr,rmarkdown,testthat,devtools |
| Published: | 2022-05-02 |
| DOI: | 10.32614/CRAN.package.replicateBE |
| Author: | Helmut Schütz [aut, cre], Michael Tomashevskiy [ctb], Detlew Labes [ctb] |
| Maintainer: | Helmut Schütz <helmut.schuetz at bebac.at> |
| BugReports: | https://github.com/Helmut01/replicateBE/issues |
| License: | GPL (≥ 3) |
| URL: | https://github.com/Helmut01/replicateBE |
| NeedsCompilation: | no |
| Materials: | README,NEWS |
| In views: | ClinicalTrials |
| CRAN checks: | replicateBE results |
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