gsDesign2: Group Sequential Design with Non-Constant Effect
The goal of 'gsDesign2' is to enable fixed or group sequential design under non-proportional hazards. To enable highly flexible enrollment, time-to-event and time-to-dropout assumptions, 'gsDesign2' offers piecewise constant enrollment, failure rates, and dropout rates for a stratified population. This package includes three methods for designs: average hazard ratio, weighted logrank tests in Yung and Liu (2019) <doi:10.1111/biom.13196>, and MaxCombo tests. Substantial flexibility on top of what is in the 'gsDesign' package is intended for selecting boundaries.
| Version: | 1.1.7 |
| Depends: | R (≥ 4.1.0) |
| Imports: | corpcor,data.table,dplyr,gsDesign,gt, methods,mvtnorm,npsurvSS (≥ 1.1.0),r2rtf, stats,survival,tibble,tidyr, utils,Rcpp |
| LinkingTo: | Rcpp |
| Suggests: | covr,ggplot2,cowplot,kableExtra,knitr,rmarkdown,simtrial,testthat (≥ 3.0.0) |
| Published: | 2025-11-19 |
| DOI: | 10.32614/CRAN.package.gsDesign2 |
| Author: | Keaven Anderson [aut], Yujie Zhao [aut, cre], Yilong Zhang [aut], John Blischak [aut], Yihui Xie [aut], Nan Xiao [aut], Jianxiao Yang [aut], Amin Shirazi [ctb], Ruixue Wang [ctb], Yi Cui [ctb], Ping Yang [ctb], Xin Tong Li [ctb], Chenxiang Li [ctb], Hiroaki Fukuda [ctb], Hongtao Zhang [ctb], Yalin Zhu [ctb], Shiyu Zhang [ctb], Dickson Wanjau [ctb], Merck & Co., Inc., Rahway, NJ, USA and its affiliates [cph] |
| Maintainer: | Yujie Zhao <yujie.zhao at merck.com> |
| BugReports: | https://github.com/Merck/gsDesign2/issues |
| License: | GPL-3 |
| URL: | https://merck.github.io/gsDesign2/,https://github.com/Merck/gsDesign2 |
| NeedsCompilation: | yes |
| Materials: | README,NEWS |
| CRAN checks: | gsDesign2 results |
Documentation:
| Reference manual: | gsDesign2.html ,gsDesign2.pdf |
| Vignettes: | Quick start for NPH sample size and power (source,R code) |
Downloads:
| Package source: | gsDesign2_1.1.7.tar.gz |
| Windows binaries: | r-devel:gsDesign2_1.1.7.zip, r-release:gsDesign2_1.1.7.zip, r-oldrel:gsDesign2_1.1.7.zip |
| macOS binaries: | r-release (arm64):gsDesign2_1.1.7.tgz, r-oldrel (arm64):gsDesign2_1.1.7.tgz, r-release (x86_64):gsDesign2_1.1.7.tgz, r-oldrel (x86_64):gsDesign2_1.1.7.tgz |
| Old sources: | gsDesign2 archive |
Reverse dependencies:
| Reverse suggests: | simtrial |
Linking:
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