Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for support functions like preconditioned fits <doi:10.1208/s12248-016-9866-5>, boostrap and stepwise covariate selection.
| Version: | 5.0.0 |
| Depends: | R (≥ 4.0) |
| Imports: | checkmate,cli (≥ 3.4.0),crayon,data.table,digest,dplyr,ggplot2,ggtext,knitr,lotri, methods,nlme,nlmixr2est (≥5.0.0),Rcpp,rxode2 (≥ 5.0.0), stats,symengine, utils |
| LinkingTo: | Rcpp,RcppArmadillo |
| Suggests: | brms,nlmixr2data,testthat (≥ 3.0.0),withr,devtools |
| Published: | 2025-11-29 |
| DOI: | 10.32614/CRAN.package.nlmixr2extra |
| Author: | Matthew Fidler [aut, cre], Vipul Mann [aut], Vishal Sarsani [aut], Christian Bartels [ctb], Bill Denney [aut] |
| Maintainer: | Matthew Fidler <matthew.fidler at gmail.com> |
| BugReports: | https://github.com/nlmixr2/nlmixr2extra/issues/ |
| License: | GPL (≥ 3) |
| URL: | https://nlmixr2.github.io/nlmixr2extra/,https://github.com/nlmixr2/nlmixr2extra/ |
| NeedsCompilation: | yes |
| Citation: | nlmixr2extra citation info |
| Materials: | README,NEWS |
| CRAN checks: | nlmixr2extra results |