Methods to evaluate the performance characteristics of various point and interval estimators for optimal adaptive two-stage designs as described in Meis et al. (2024) <doi:10.1002/sim.10020>. Specifically, this package is written to work with trial designs created by the 'adoptr' package (Kunzmann et al. (2021) <doi:10.18637/jss.v098.i09>; Pilz et al. (2021) <doi:10.1002/sim.8953>)). Apart from the a priori evaluation of performance characteristics, this package also allows for the evaluation of the implemented estimators on real datasets, and it implements methods to calculate p-values.
| Version: | 1.0.0 |
| Depends: | R (≥ 4.0.0),adoptr |
| Imports: | methods, stats, grDevices,cubature,ggplot2,ggpubr,scales,latex2exp,forcats,future.apply,progressr,Rdpack |
| Suggests: | covr,knitr,rmarkdown,testthat (≥ 3.0.0),microbenchmark |
| Published: | 2024-07-12 |
| DOI: | 10.32614/CRAN.package.adestr |
| Author: | Jan Meis [aut, cre], Martin Maechler [cph] (Original author of monoSpl.c (from the 'stats' package).) |
| Maintainer: | Jan Meis <meis at imbi.uni-heidelberg.de> |
| License: | GPL-2 |GPL-3 [expanded from: GPL (≥ 2)] |
| Copyright: | This package contains a modified version of the monotonicspline functions from the 'stats' package. Specifically, thecode is containted in the files 'R/fastmonoHFC.R','src/fastmonoHFC.c', 'src/modreg.h' and 'src/monoSpl.c'. The RCore team and Martin Maechler are the copyright holders of theoriginal code. Jan Meis is the copyright holder of everythingelse. |
| URL: | https://jan-imbi.github.io/adestr/ |
| NeedsCompilation: | yes |
| Citation: | adestr citation info |
| Materials: | README,NEWS |
| In views: | ClinicalTrials |
| CRAN checks: | adestr results |