Movatterモバイル変換

rpact

Confirmatory Adaptive Clinical Trial Design, Simulation, andAnalysis.

Functional Range

• Fixed sample design and designs with interim analysis stages
• Sample size and power calculation for
  • means (continuous endpoint)
  • rates (binary endpoint)
  • survival trials with flexible recruitment and survival timeoptions
  • count data
• Simulation tool for means, rates, survival data, and count data
  • Assessment of adaptive sample size/event number recalculations basedon conditional power
  • Assessment of treatment selection strategies in multi-armtrials
• Adaptive analysis of means, rates, and survival data
• Adaptive designs and analysis for multi-arm trials
• Adaptive analysis and simulation tools for enrichment design testingmeans, rates, and hazard ratios
• Automatic boundary recalculations during the trial for analysis withalpha spending approach, including under- and over-running

Installation

Install the latest CRAN release via

install.packages("rpact")

Development version

To use a feature from the development version, you can install thedevelopment version of rpact fromGitHub.

# install.packages("pak")pak::pak("rpact-com/rpact")

Documentation

The documentation is hosted atwww.rpact.org

Vignettes

The vignettes are hosted atwww.rpact.org/vignettes

RPACT Connect

Connecting you to insights, downloads, and premium support:connect.rpact.com

The RPACT User Group

Therpact project has an active user group consisting ofdecision-makers and users from the pharmaceutical industry and CROs, whomeet regularly and, e.g., discuss best practices.

We invite you to be part of theRPACT User Group: benefitfrom know-how, shape open source development in Pharma!

Use on corporate computersystems

Pleasecontact us tolearn how to userpact on FDA/GxP-compliant validatedcorporate computer systems and how to get a copy of the formalvalidation documentation that is customized and licensed for exclusiveuse by your company, e.g., to fulfill regulatory requirements. Thevalidation documentation contains the personal access data forperforming the installation qualification withtestPackage().

www.rpact.com/contact

About

• rpact is a comprehensive validated¹ Rpackage for clinical research which
  • enables the design and analysis of confirmatory adaptive groupsequential designs
  • is a powerful sample size calculator
  • is a free of charge open-source software licensed underLGPL-3
  • particularly, implements the methods described in the recentmonograph byWassmer and Brannath(2025)

For more information please visitwww.rpact.org

• RPACT is a company which offers
  • enterprise R/Shiny software development services
  • technical support for therpact package
  • consultancy and user training for scientists using R
  • validated software solutions and R package development for clinicalresearch

For more information please visitwww.rpact.com