grantham: Calculate the Grantham Distance
A minimal set of routines to calculate the Grantham distance <doi:10.1126/science.185.4154.862>. The Grantham distance attempts to provide a proxy for the evolutionary distance between two amino acids based on three key chemical properties: composition, polarity and molecular volume. In turn, evolutionary distance is used as a proxy for the impact of missense mutations. The higher the distance, the more deleterious the substitution is expected to be.
| Version: | 0.1.4 |
| Depends: | R (≥ 4.1.0) |
| Imports: | tibble,dplyr |
| Suggests: | spelling,testthat (≥ 3.0.0) |
| Published: | 2025-05-31 |
| DOI: | 10.32614/CRAN.package.grantham |
| Author: | Ramiro Magno [aut, cre], Isabel Duarte [aut], Ana-Teresa Maia [aut], University of Algarve [fnd], CINTESIS [fnd], Pattern Institute [cph, fnd] |
| Maintainer: | Ramiro Magno <rmagno at pattern.institute> |
| BugReports: | https://github.com/patterninstitute/grantham/issues |
| License: | MIT + fileLICENSE |
| URL: | https://www.pattern.institute/grantham/,https://github.com/patterninstitute/grantham |
| NeedsCompilation: | no |
| Language: | en-US |
| Materials: | README,NEWS |
| CRAN checks: | grantham results |
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