Simulate dose regimens for pharmacokinetic-pharmacodynamic (PK-PD) models described by differential equation (DE) systems. Simulation using ADVAN-style analytical equations is also supported (Abuhelwa et al. (2015) <doi:10.1016/j.vascn.2015.03.004>).
| Version: | 1.4.1 |
| Depends: | R (≥ 4.0.0) |
| Imports: | Rcpp (≥ 1.0.13),BH,data.table,stringr,MASS,randtoolbox,jsonlite, stats, parallel,magrittr |
| LinkingTo: | BH,Rcpp (≥ 1.0.13) |
| Suggests: | httr,testthat (≥ 3.0.0),mockery,knitr,rmarkdown |
| Published: | 2025-04-17 |
| DOI: | 10.32614/CRAN.package.PKPDsim |
| Author: | Ron Keizer [aut, cre], Jasmine Hughes [aut], Dominic Tong [aut], Kara Woo [aut], Jordan Brooks [aut], InsightRX [cph, fnd] |
| Maintainer: | Ron Keizer <ron at insight-rx.com> |
| License: | MIT + fileLICENSE |
| URL: | https://github.com/InsightRX/PKPDsim,https://insightrx.github.io/PKPDsim/ |
| NeedsCompilation: | yes |
| Language: | en-US |
| Materials: | README,NEWS |
| In views: | MixedModels,Pharmacokinetics |
| CRAN checks: | PKPDsim results |
| Reference manual: | PKPDsim.html ,PKPDsim.pdf |
| Vignettes: | Covariates (source,R code) Absorption models (source,R code) Export model (source,R code) Model (source,R code) Output (source,R code) Parameters (source,R code) Regimen (source,R code) Simulation (source,R code) Speed (source) |
| Package source: | PKPDsim_1.4.1.tar.gz |
| Windows binaries: | r-devel:PKPDsim_1.4.1.zip, r-release:PKPDsim_1.4.1.zip, r-oldrel:PKPDsim_1.4.1.zip |
| macOS binaries: | r-release (arm64):PKPDsim_1.4.1.tgz, r-oldrel (arm64):PKPDsim_1.4.1.tgz, r-release (x86_64):PKPDsim_1.4.1.tgz, r-oldrel (x86_64):PKPDsim_1.4.1.tgz |
| Old sources: | PKPDsim archive |
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