A collection of clinical trial designs and methods, implemented in 'rstan' and R, including: the Continual Reassessment Method by O'Quigley et al. (1990) <doi:10.2307/2531628>; EffTox by Thall & Cook (2004) <doi:10.1111/j.0006-341X.2004.00218.x>; the two-parameter logistic method of Neuenschwander, Branson & Sponer (2008) <doi:10.1002/sim.3230>; and the Augmented Binary method by Wason & Seaman (2013) <doi:10.1002/sim.5867>; and more. We provide functions to aid model-fitting and analysis. The 'rstan' implementations may also serve as a cookbook to anyone looking to extend or embellish these models. We hope that this package encourages the use of Bayesian methods in clinical trials. There is a preponderance of early phase trial designs because this is where Bayesian methods are used most. If there is a method you would like implemented, please get in touch.
| Version: | 0.1.6 |
| Depends: | R (≥ 3.5.0), methods,Rcpp (≥ 1.0.1) |
| Imports: | rstan (≥ 2.18.2),rstantools (≥ 1.5.1),rlang (≥ 0.4.5),dplyr,purrr,magrittr,stringr,ggplot2,gtools,coda,tidybayes (≥ 2.0.3),tibble (≥ 3.0.0),binom,MASS |
| LinkingTo: | StanHeaders (≥ 2.18.1),rstan (≥ 2.18.2),BH (≥1.69.0-1),Rcpp (≥ 1.0.1),RcppEigen (≥ 0.3.3.5.0),RcppParallel (≥ 5.0.2) |
| Suggests: | testthat,knitr,rmarkdown,tidyr,ggridges,DiagrammeR |
| Published: | 2023-03-12 |
| DOI: | 10.32614/CRAN.package.trialr |
| Author: | Kristian Brock [aut, cre], Trustees of Columbia University [cph] |
| Maintainer: | Kristian Brock <kristian.brock at gmail.com> |
| BugReports: | https://github.com/brockk/trialr/issues |
| License: | GPL (≥ 3) |
| URL: | https://github.com/brockk/trialr |
| NeedsCompilation: | yes |
| SystemRequirements: | GNU make |
| Materials: | README,NEWS |
| CRAN checks: | trialr results |