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RTSA: 'Trial Sequential Analysis' for Error Control and Inference inSequential Meta-Analyses

Frequentist sequential meta-analysis based on 'Trial Sequential Analysis' (TSA) in programmed in Java by the Copenhagen Trial Unit (CTU). The primary function is the calculation of group sequential designs for meta-analysis to be used for planning and analysis of both prospective and retrospective sequential meta-analyses to preserve type-I-error control under sequential testing. 'RTSA' includes tools for sample size and trial size calculation for meta-analysis and core meta-analyses methods such as fixed-effect and random-effects models and forest plots. TSA is described in Wetterslev et. al (2008) <doi:10.1016/j.jclinepi.2007.03.013>. The methods for deriving the group sequential designs are based on Jennison and Turnbull (1999, ISBN:9780849303166).

Version:0.2.2
Depends:R (≥ 3.5.0)
Imports:stats,metafor,ggplot2,scales,Rcpp (≥ 0.11.0)
LinkingTo:Rcpp
Suggests:gsDesign,CompQuadForm,dplyr,kableExtra,rmarkdown,knitr,bookdown,gridExtra,testthat (≥ 3.0.0)
Published:2023-11-23
DOI:10.32614/CRAN.package.RTSA
Author:Anne Lyngholm Soerensen [aut, cre, trl], Markus Harboe Olsen [aut, ctr], Theis Lange [ctr], Christian Gluud [ctr]
Maintainer:Anne Lyngholm Soerensen <lynganne at gmail.com>
BugReports:https://github.com/AnneLyng/RTSA/issues
License:GPL-2 |GPL-3 [expanded from: GPL (≥ 2)]
URL:https://github.com/AnneLyng/RTSA
NeedsCompilation:yes
Materials:README
In views:MetaAnalysis
CRAN checks:RTSA results

Documentation:

Reference manual:RTSA.html ,RTSA.pdf
Vignettes:RTSA - Standard operational protocol (source,R code)
Rtsa manual (source,R code)
Futility boundaries in RTSA (source,R code)
Prospective and retrospective sequential meta-analysis (source,R code)
Calculating required sample size and required number of trials (source,R code)

Downloads:

Package source: RTSA_0.2.2.tar.gz
Windows binaries: r-devel:RTSA_0.2.2.zip, r-release:RTSA_0.2.2.zip, r-oldrel:RTSA_0.2.2.zip
macOS binaries: r-release (arm64):RTSA_0.2.2.tgz, r-oldrel (arm64):RTSA_0.2.2.tgz, r-release (x86_64):RTSA_0.2.2.tgz, r-oldrel (x86_64):RTSA_0.2.2.tgz
Old sources: RTSA archive

Linking:

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