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PopED

PopED computes optimal experimental designs for both population andindividual studies based on nonlinear mixed-effect models. Often this isbased on a computation of the Fisher Information Matrix (FIM).

Installation

You need to have R installed. Download the latest version of R fromwww.r-project.org. You can install the released version of PopED fromCRAN with:

install.packages("PopED")

And the development version fromGitHub with:

# install.packages("devtools")devtools::install_github("andrewhooker/PopED")

Getting started

To get started you need to define

1. A model.
2. An initial design (and design space if you want to optimize).
3. The tasks to perform.

Learn more in thisintroductionto PopED

Contact

You are welcome to:

• Ask questions at:https://github.com/andrewhooker/PopED/discussions
• submit suggestions and bug-reports at:https://github.com/andrewhooker/PopED/issues
• send a pull request on:https://github.com/andrewhooker/PopED
• compose a friendly e-mail to:andrew.hooker@farmaci.uu.se