Movatterモバイル変換

[0]ホーム
URL:

Skip to content
MIT Official WebsiteMIT Official Website
H. Robert Horvitz

H. Robert Horvitz

David H. Koch Professor; Member, McGovern Institute for Brain Research; Member, David H. Koch Institute for Integrative Cancer Research; Investigator, Howard Hughes Medical Institute

H. Robert Horvitz analyzes the roles of genes in animal development and behavior, gaining insight into human disease.

68-425

Office

Building 68 - Koch Biology Building

Location

Sally Shin

Assistant

617-253-3162

Assistant Phone

Education

  • PhD, 1974, Harvard University
  • BS, 1968, Mathematics and Economics, MIT

Research Summary

Our lab examines how genes control animal development and behavior. We use the experimentally tractable nematodeCaenorhabditis elegans to identify and analyze molecular and cellular pathways involved in these important areas of biology. Ultimately, we hope to clarify these fundamental biological mechanisms and provide further insight into human disease.

Awards

  • U.S. National Academy of Inventors, Member, 2015
  • American Association for Cancer Research Academy, Fellow, 2013
  • Royal Society of London, Foreign Member, 2009
  • Genetics Society (U.K.), Mendel Medal, 2007
  • Eli Lilly Lecturer Award, 2007
  • Massachusetts Institute of Technology, James R Killian Jr Faculty Achievement Award, 2006
  • National Academy of Medicine, Member, 2003
  • American Cancer Society, Medal of Honor, 2002
  • The Nobel Foundation, Nobel Prize in Physiology or Medicine, 2002
  • Bristol-Myers Squibb, Award for Distinguished Achievement in Neuroscience, 2001
  • March of Dimes, Developmental Biology, 2000
  • Gairdner Foundation, Gairdner Foundation International Award, 1999
  • National Academy of Sciences, Member, 1991
  • American Academy of Arts and Sciences, Fellow, 1989
  • American Association for the Advancement of Science, Fellow, 1989
  • Howard Hughes Medical Institute, HHMI Investigator, 1988

Key Publications

  1. Replication stress promotes cell elimination by extrusion. Dwivedi, VK, Pardo-Pastor, C, Droste, R, Kong, JN, Tucker, N, Denning, DP, Rosenblatt, J, Horvitz, HR. 2021. Nature 593, 591-596.
    doi:10.1038/s41586-021-03526-yPMID:33953402
  2. C. elegans discriminates colors to guide foraging. Ghosh, DD, Lee, D, Jin, X, Horvitz, HR, Nitabach, MN. 2021. Science 371, 1059-1063.
    doi:10.1126/science.abd3010PMID:33674494
  3. Hypoxia-inducible factor cell non-autonomously regulatesC. elegans stress responses and behavior via a nuclear receptor. Pender, CL, Horvitz, HR. 2018. Elife 7, .
    doi:10.7554/eLife.36828PMID:30010540
  4. Genetic control of programmed cell death in the nematode C. elegans. Ellis, HM, Horvitz, HR. 1986. Cell 44, 817-29.
    doi:10.1016/0092-8674(86)90004-8PMID:3955651
  5. Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Sulston, JE, Horvitz, HR. 1977. Dev Biol 56, 110-56.
    doi:10.1016/0012-1606(77)90158-0PMID:838129

Recent Publications

  1. From nematode to Nobel: How community-shared resources fueled the rise ofCaenorhabditis elegans as a research organism. Ambros, VR, Chalfie, M, Daul, AL, Fire, AZ, Hall, DH, Horvitz, HR, Mello, CC, Ruvkun, G, Schroeder, NE, Sternberg, PWet al.. 2025. Proc Natl Acad Sci U S A 122, e2522808122.
    doi:10.1073/pnas.2522808122PMID:41284858
  2. The pro-apoptotic function of theC. elegans BCL-2 homolog CED-9 requires interaction with the APAF-1 homolog CED-4. Tucker, N, Reddien, P, Hersh, B, Lee, D, Liu, MHX, Horvitz, HR. 2024. Sci Adv 10, eadn0325.
    doi:10.1126/sciadv.adn0325PMID:39383227
  3. Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior. Ahumada-Marchant, C, Ancatén-Gonzalez, C, Haensgen, H, Brauer, B, Merino-Veliz, N, Droste, R, Arancibia, F, Horvitz, HR, Constantine-Paton, M, Arriagada, Get al.. 2024. BMC Biol 22, 142.
    doi:10.1186/s12915-024-01940-yPMID:38926759
  4. A DEAD-box helicase drives the partitioning of a pro-differentiation NAB protein into nuclear foci. Doi, A, Suarez, GD, Droste, R, Horvitz, HR. 2023. Nat Commun 14, 6593.
    doi:10.1038/s41467-023-42345-9PMID:37852948
  5. Deletion of VPS50 protein in mice brain impairs synaptic function and behavior. Ahumada-Marchant, C, Ancatén-Gonzalez, C, Haensgen, H, Arancibia, F, Brauer, B, Droste, R, Horvitz, HR, Constantine-Paton, M, Arriagada, G, Chávez, AEet al.. 2023. bioRxiv , .
    doi:10.1101/2023.07.04.547745PMID:37461727
  6. The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity inCaenorhabditis elegans. Saul, J, Hirose, T, Horvitz, HR. 2022. Elife 11, .
    doi:10.7554/eLife.74557PMID:35119366
  7. An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction. Sando, SR, Bhatla, N, Lee, EL, Horvitz, HR. 2021. Elife 10, .
    doi:10.7554/eLife.59341PMID:34212858
  8. Replication stress promotes cell elimination by extrusion. Dwivedi, VK, Pardo-Pastor, C, Droste, R, Kong, JN, Tucker, N, Denning, DP, Rosenblatt, J, Horvitz, HR. 2021. Nature 593, 591-596.
    doi:10.1038/s41586-021-03526-yPMID:33953402
  9. C. elegans discriminates colors to guide foraging. Ghosh, DD, Lee, D, Jin, X, Horvitz, HR, Nitabach, MN. 2021. Science 371, 1059-1063.
    doi:10.1126/science.abd3010PMID:33674494
  10. H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect. Burkhart, KB, Sando, SR, Corrionero, A, Horvitz, HR. 2020. Curr Biol 30, 2343-2352.e3.
    doi:10.1016/j.cub.2020.04.046PMID:32470364
More Publications

Multimedia

 

 

 

 

[8]ページ先頭
©2009-2025 Movatter.jp