时长:00:18:45 / 首播:2017-03-30
Sheldon and Amy attempt to analyze the Copenhagen interpretation using the neurobiology of decision-making. Professionally collaborating for the first time, they try to be nice for the sake of their relationship, but their work is of poor quality. They find that insulting each other makes them more creative, so they compile a list of topics that they can insult each other with. Meanwhile, Penny and Raj bond over girly things, causing Leonard to feel left out. Howard and Bernadette suggest that he talk to them, but Raj and Penny talk about Leonard's feelings while ignoring him.
Title reference: Sheldon and Amy collaborating, first cooperating then arguing.