Michonne tends to work alone and quietly and keeps much of her past secret, even towards Andrea, but possesses a keen sense of intuition. Michonne once said that she "trusts her gut" when it comes to other survivors. After the loss of her boyfriend, she suffered from hallucinations in which she would talk to him. It was revealed that she likes art and/or sculptures as she looted a cat sculpture and claimed that it was "too damn gorgeous" to leave behind. As time goes on she gradually opens up to the group, specifically Rick and Carl, and becomes accepted by the whole group.

Michonne appeared to have an aversion to babies, as she vehemently refused to hold Judith until Beth Green forced her to, and, while looking at Judith, shed tears, before hugging Judith close. Michonne later establishes that this is a manifestation of the guilt she feels for losing her own son, Andre.