OBSOLETE. A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.Source:GOC:dph,GOC:tb
Comment
The reason for obsoletion is that these activities are not necessarily specific for nuclear receptors subclass of dbTFs, so that distinction leads to misannotations.
Linkto allgenes and gene products annotated to obsolete nuclear receptor coactivator activity (excluding "regulates").
Linkto all direct and indirectannotationsto obsolete nuclear receptor coactivator activity (excluding "regulates").
Linkto all direct and indirectannotations download (limited to first 10,000)for obsolete nuclear receptor coactivator activity (excluding "regulates").
